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I've just completed a project where I was the Rails developer for a site that was integrating a Flex application that needed to pull from a database. A primary consideration is how to transport the data. Rails supports xml and json natively, and is very easy to set up by adding a single line to a controller's respond_to method. Sasha, the Flex developer on the project, suggested that we go with AMF if possible as it's native to Flex and is deserialized straight into custom typed objects.
After reading a bit about some performance considerations it looks like AMF and JSON are going to get roughly similar performance in most cases, so it becomes a matter of ease of development and taste. Sasha definitely preferred working with AMF, so i started checking out Rails implementations.
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